| Alien Resurrection | 2000 | Argonaut Games | PlayStation |
| Formula One 2000 | 2000 | Studio 33 | PlayStation |
| Micro Maniacs | 2000 | Codemasters | PlayStation |
| Muppet RaceMania | 2000 | Traveller's Tales | PlayStation |
| Speedball 2100 | 2000 | The Bitmap Brothers | PlayStation |
| Buzz Lightyear of Star Command | 2000 | Traveller's Tales | PlayStation, Microsoft Windows, Dreamcast, Game Boy Color |
| Spin Jam | 2000 | — | PlayStation, PlayStation 3, PlayStation Portable, PlayStation Vita |
| Frogger 2: Swampy's Revenge | 2000 | Blitz Games | Microsoft Windows, Dreamcast |
| Galaga: Destination Earth | 2000 | — | PlayStation, Microsoft Windows |
| Austin Powers: Welcome to My Underground Lair! | 2000 | Rockstar Lincoln | Game Boy Color |
| O'Leary Manager 2000 | 2000 | — | Game Boy Color |
| Team Buddies | 2000 | SCE Studio Liverpool | PlayStation |
| Wild Wild Racing | 2000 | Rage Games | PlayStation 2 |
| Lego Stunt Rally | 2000 | Graphic State Games | Microsoft Windows |
| Carmageddon TDR 2000 | 2000 | Torus Games | Microsoft Windows |
| Perfect Dark | 2000 | Rare Ltd. | Game Boy Color |
| Terracon | 2000 | Palace Cinema | PlayStation |
| Grand Prix 3 | 2000 | MicroProse | Microsoft Windows |
| ATV Quad Power Racing | 2000 | Climax Studios | PlayStation, Game Boy Advance |
| Deep Fighter | 2000 | Criterion Games | Microsoft Windows, Dreamcast |
| RC Revenge | 2000 | Acclaim Entertainment | PlayStation |
| Robot Warlords | 2000 | — | PlayStation 2 |
| Submarine TITANS | 2000 | — | Microsoft Windows |
| Play with the Teletubbies | 2000 | Ragdoll Productions | PlayStation, Microsoft Windows |
| Urban Terror | 2000 | — | Microsoft Windows, macOS, Linux |
| Hot Chix 'n' Gear Stix | 2000 | Driver-Inter, Ltd., Fiendish Games | Microsoft Windows |
| Taz Express | 2000 | — | Nintendo 64 |
| Spirit of Speed 1937 | 2000 | — | Dreamcast |
| Sydney 2000 | 2000 | Attention to Detail | PlayStation, Microsoft Windows, Dreamcast |
| Dogs of War | 2000 | Silicon Dreams Studios | Microsoft Windows |
| Warlocked | 2000 | Bits Studios | Game Boy Color |
| Destruction Derby Raw | 2000 | Studio 33 | PlayStation |
| Soulbringer | 2000 | Suntendy Interactive Multimedia Co.,Ltd., Infogrames | Microsoft Windows |
| The F.A. Premier League Stars | 2000 | Electronic Arts | PlayStation, Microsoft Windows |
| Star Trek: Invasion | 2000 | Warthog Games | PlayStation |
| Deus Ex | 2000 | Ion Storm | PlayStation 2, PlayStation 3, Classic Mac OS, Microsoft Windows, Mac operating system |
| Fur Fighters | 2000 | Bizarre Creations | PlayStation 2, Microsoft Windows, Dreamcast, iOS |
| Caesars Palace 2000 | 2000 | Runecraft | PlayStation, Microsoft Windows, Dreamcast |
| Shogun: Total War | 2000 | Creative Assembly | Microsoft Windows |
| Tomb Raider | 2000 | Core Design | Game Boy Color |
| Hogs of War | 2000 | Infogrames | PlayStation, Microsoft Windows |
| F1 Championship Season 2000 | 2000 | Image Space Incorporated | PlayStation, PlayStation 2, macOS, personal computer, Game Boy Advance |
| BCV: Battle Construction Vehicles | 2000 | Artdink | PlayStation 2 |
| Evolva | 2000 | — | Microsoft Windows |
| Power Rangers Lightspeed Rescue | 2000 | Mass Media Inc. | PlayStation, Classic Mac OS, Microsoft Windows, Nintendo 64, Game Boy Advance |
| Nushi Tsuri 64: Shiokaze Ninotte | 2000 | VIS Entertainment | Nintendo 64 |
| Perfect Dark | 2000 | Rare Ltd. | Nintendo 64, Xbox 360 |
| Skyhammer | 2000 | Rebellion Developments | Atari Jaguar |
| Metal Fatigue | 2000 | Zono | Microsoft Windows |
| Colony Wars: Red Sun | 2000 | SCE Studio Liverpool | PlayStation |
| Martian Gothic: Unification | 2000 | — | PlayStation, Microsoft Windows |
| Master of the Skies: The Red Ace | 2000 | — | Microsoft Windows |
| Lemmings Revolution | 2000 | Take-Two Interactive | Microsoft Windows |
| Grudge Warriors | 2000 | — | PlayStation |
| Airport Tycoon | 2000 | Krisalis Software | Microsoft Windows |
| MediEvil 2 | 2000 | Guerrilla Cambridge | PlayStation |
| Red Dog: Superior Firepower | 2000 | Argonaut Games | Dreamcast |
| Daikatana | 2000 | Ion Storm, Kemco | Microsoft Windows, Nintendo 64, Game Boy Color |
| Jimmy White's 2: Cueball | 2000 | UTV Ignition Games | PlayStation, PlayStation 2, Microsoft Windows, Dreamcast |
| Pajama Sam 3: You Are What You Eat from Your Head to Your Feet | 2000 | Humongous Entertainment | PlayStation, Classic Mac OS, Microsoft Windows, macOS, Nintendo Switch, Linux, iOS, PlayStation 4, Android |