| Z | 1996 | The Bitmap Brothers | PlayStation, Microsoft Windows, macOS, DOS, Sega Saturn, iOS, Android |
| Z: Steel Soldiers | 2001 | The Bitmap Brothers | Microsoft Windows, iOS, Android |
| Z: Steel Soldiers (2014) | 2014 | TickTock Games | Microsoft Windows |
| Zapper: One Wicked Cricket | 2002 | Blitz Games | PlayStation 2, Xbox, Microsoft Windows, Nintendo GameCube, Game Boy Advance |
| Zarathrusta | 1991 | The Whiz Kidz | Commodore Amiga |
| Zarch | 1987 | David Braben | DOS, ZX Spectrum, Acorn Archimedes |
| Zeewolf | 1994 | — | Commodore Amiga |
| Zen Fish SIM | 2014 | Irongames Studio | Microsoft Windows, Linux |
| Zendoku | 2007 | Zoonami | Nintendo DS |
| Zero 5 | 1997 | — | Atari Jaguar |
| Zero 5 | 1994 | — | Atari ST |
| Zero Escape: Virtue's Last Reward | 2012 | Chunsoft | Xbox One, Microsoft Windows, PlayStation Vita, Nintendo 3DS, PlayStation 4 |
| Zero Parades: For Dead Spies | 2026 | ZA/UM | Microsoft Windows, PlayStation 5 |
| Zeus: Master of Olympus | 2000 | Impressions Games | Microsoft Windows |
| Zhadnost: The People's Party | 1995 | — | 3DO |
| Zig Zag | 1987 | — | Commodore 64 |
| Zig Zag | 1984 | — | ZX Spectrum, Commodore 64 |
| Zip Zap | 1983 | Ian Weatherburn | ZX Spectrum |
| Zipple World | 2016 | — | Microsoft Windows |
| Zipple World 2: The Sweet Chaos | 2016 | — | Microsoft Windows |
| Zodiac | 1987 | — | Commodore 64 |
| Zoids: The Battle Begins | 1986 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Zombie Army 4: Dead War | 2020 | Rebellion Developments | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Zombie Army Trilogy | 2015 | Rebellion Developments | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Zombie Massacre | 1998 | — | Commodore Amiga |
| Zombie Pirates | 2010 | — | Microsoft Windows |
| Zombie Zombie | — | — | ZX Spectrum |
| Zombies, Run! | 2012 | — | watchOS, iOS, Android |
| Zone Hunter | — | — | arcade video game machine |
| Zone Raiders | 1995 | Image Space Incorporated | Classic Mac OS, DOS |
| Zoo Hospital | 2008 | Torus Games | Nintendo DS, Wii |
| Zoo Park | 2014 | — | Microsoft Windows |
| Zoo Tycoon | 2013 | Frontier Developments | Xbox One, Xbox 360 |
| ZooCube | 2002 | — | PlayStation 2, Nintendo GameCube, Game Boy Advance |
| Zool | 1992 | Gremlin Interactive | Commodore Amiga, Sega Genesis/Mega Drive, DOS, BlackBerry, Super Nintendo Entertainment System, Sega Master System, Acorn Archimedes, Atari ST, Amiga CD32, Game Gear |
| Zool 2 | 1993 | Gremlin Interactive | Microsoft Windows, DOS, Amiga 1200, Atari Jaguar, Amiga CD32 |
| Zool Redimensioned | 2021 | — | Microsoft Windows, PlayStation 4 |
| Zoombini Island Odyssey | — | The Learning Company | Microsoft Windows |
| Zoop | 1995 | — | Sega Genesis/Mega Drive, PlayStation, Classic Mac OS, Microsoft Windows, DOS, Super Nintendo Entertainment System, Game Gear |
| Zub | 1986 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Zubo | 2008 | Electronic Arts | Nintendo DS |
| Zulu | — | — | Commodore 64 |
| Zumba Burn It Up! | 2019 | Kuju Ltd. | Nintendo Switch |
| Zumba Fitness 2 | 2011 | Zoë Mode | Xbox 360, Wii |
| Zumba Fitness Core | 2012 | Zoë Mode | Xbox 360, Wii |
| Zumba Fitness: World Party | 2013 | Zoë Mode | Xbox One, Xbox 360, Wii |
| Zumba Kids | 2013 | Zoë Mode | Xbox 360, Wii |
| Zybex | 1989 | — | ZX Spectrum, Commodore 64 |
| Zynaps | 1987 | Dominic Robinson | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Zzoom | 1983 | — | Microsoft Windows, ZX Spectrum |