| E-Motion | 1990 | The Assembly Line | Commodore Amiga, DOS, Game Boy, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| E-Racer | 2001 | Rage Games | Microsoft Windows |
| E-Type | 1989 | Gordon J. Key | Acorn Archimedes |
| EA Sports FIFA Superstars | 2010 | Electronic Arts, Playfish | Facebook Platform, iOS |
| EA Sports WRC | 2023 | Codemasters | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Eagle One: Harrier Attack | 2000 | — | PlayStation |
| Eagles | 1987 | — | Commodore 64 |
| Earache: Extreme Metal Racing | 2006 | Data Design Interactive | PlayStation 2, Microsoft Windows |
| Earth 2150: Lost Souls | 2002 | TopWare Interactive | Microsoft Windows |
| Earth Defense Force 4.1: The Shadow of New Despair | 2015 | Sandlot | Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Earth Must Die | 2026 | — | Microsoft Windows, Nintendo Switch, PlayStation 5 |
| Earth Shaker | 1990 | — | ZX Spectrum |
| Earthlight | 1988 | — | ZX Spectrum |
| Earthworm Jim | 1994 | Shiny Entertainment | Sega Genesis/Mega Drive, Microsoft Windows, macOS, PlayStation Portable, DOS, Super Nintendo Entertainment System, Game Boy, Game Boy Advance, Sega Master System, Linux, iOS, Windows Phone+2 |
| Earthworm Jim 2 | 1995 | Shiny Entertainment | Sega Genesis/Mega Drive, PlayStation, Microsoft Windows, Super Nintendo Entertainment System, Game Boy Advance, Linux |
| Earthworm Jim 3D | 1999 | VIS Entertainment | Microsoft Windows, Nintendo 64 |
| EastEnders | 1987 | Macsen Software | ZX Spectrum |
| Easter Riddles | 2021 | Creobit | Microsoft Windows |
| Eastside Hockey Manager | 2015 | Sports Interactive | Microsoft Windows |
| Echobreaker | 2026 | Upstream Arcade | Microsoft Windows |
| Echoes of the End | 2025 | Myrkur Games | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Ecks vs. Sever | 2001 | Crawfish Interactive | Game Boy Advance |
| Eco | 1987 | Denton Designs | Commodore Amiga, Atari ST |
| Eco Tycoon: Project Green | 2009 | Virtual Playground | Microsoft Windows |
| Ecstatica | 1994 | — | DOS |
| Ecstatica II | 1997 | — | Microsoft Windows, DOS |
| Ed, Edd n Eddy: Jawbreakers! | 2003 | Climax Studios | Game Boy Advance |
| Eddie Kidd Jump Challenge | 1985 | Martech Games | ZX Spectrum, BBC Micro, MSX, Commodore 64 |
| Eden Star | 2015 | — | Microsoft Windows |
| Edge of Twilight: Return to Glory | 2016 | Fuzzyeyes | Microsoft Windows |
| EF2000 | 1995 | Digital Image Design | DOS |
| Egg Mania: Eggstreme Madness | 2002 | HotGen | PlayStation 2, Xbox, Nintendo GameCube, Game Boy Advance |
| Egypt Picross Pharaohs Riddles | 2020 | Somer Games | Microsoft Windows |
| Egypt Solitaire. Match 2 Cards | 2020 | Somer Games | Microsoft Windows |
| Eight Days | 2009 | London Studio | PlayStation 3 |
| El Cid | 1987 | DROsoft | ZX Spectrum, Amstrad CPC, MSX |
| Eldevin | 2014 | Hunted Cow Studios | Microsoft Windows, macOS |
| Elefunk | 2008 | — | PlayStation 3 |
| Elf | 1991 | Ocean Software | Commodore Amiga, Microsoft Windows, DOS, Atari ST |
| Elidon | 1985 | Orpheus Ltd, Aackosoft | MSX, Commodore 64 |
| Eliminator | 1999 | Magenta Software | PlayStation, Microsoft Windows |
| Eliminator | 1988 | Linel | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Elite | 1984 | David Braben, Ian Bell | Commodore Amiga, SAM Coupé, DOS, Nintendo Entertainment System, Tatung Einstein, ZX Spectrum, Apple II, Acorn Electron, Acorn Archimedes, Amstrad CPC, Atari ST, BBC Micro+2 |
| Elite Dangerous | 2014 | Frontier Developments | Xbox One, Microsoft Windows, macOS, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Elite Dangerous: Arena | 2016 | Frontier Developments | Microsoft Windows |
| Elite Dangerous: Horizons | 2015 | Frontier Developments | Microsoft Windows, macOS |
| Elite Dangerous: Odyssey | 2021 | Frontier Developments | Microsoft Windows |
| Elixir | 1987 | — | Acorn Electron |
| Elly's Cake Cafe | 2020 | Creobit | Microsoft Windows |
| Elven Warrior | 1989 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Elvira II: The Jaws of Cerberus | 1992 | Adventure Soft | Commodore Amiga, DOS, Atari ST, Commodore 64 |
| Elvira: Mistress of the Dark | 1990 | Adventure Soft | Commodore Amiga, DOS, Atari ST, Commodore 64 |
| Elvira: The Arcade Game | 1991 | Flair Software | Commodore Amiga, DOS, Atari ST, Commodore 64 |
| Embr | 2021 | Muse Games | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, Xbox Series X and Series S |
| Emerald Isle | 1984 | Level 9 Computing | ZX Spectrum, Amstrad CPC, MSX |
| Emergency 2013 | 2012 | — | Microsoft Windows |
| Emergency 2016 | 2015 | — | Microsoft Windows |
| Emergency 5 | 2014 | — | Microsoft Windows, macOS |
| Emergency Crew 2 Global Warming | 2022 | GameOn Production | Microsoft Windows |
| Emergency Crew Volcano Eruption | 2021 | GameOn Production | Microsoft Windows, PlayStation 4 |
| Emergency Heroes | 2008 | Ubisoft Reflections | Wii |
| Emergency Mayhem | 2008 | Supersonic Software | Wii |
| Emily: Displaced | 2016 | Bossa Studios | Microsoft Windows, macOS |
| Emlyn Hughes International Soccer | 1988 | — | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Emperor: Battle for Dune | 2001 | Westwood Studios, Intelligent Games | Microsoft Windows |
| Empire! | 1986 | Andrew Glaister | ZX Spectrum, MS-DOS, Amstrad CPC, Commodore 64 |
| Empire: Total War | 2009 | Creative Assembly, Feral Interactive | Microsoft Windows, macOS, Linux |
| Empire: Total War - Elite Units of America | 2009 | — | Microsoft Windows, macOS, Linux |
| Empire: Total War - Elite Units of the East | 2010 | — | Microsoft Windows, macOS, Linux |
| Empire: Total War - Elite Units of the West | 2009 | — | Microsoft Windows, macOS, Linux |
| Empire: Total War - Special Forces Units & Bonus Content | 2009 | — | Microsoft Windows, macOS, Linux |
| Empires Apart | 2018 | DESTINYbit | Microsoft Windows |
| Empires of the Undergrowth | 2017 | — | Microsoft Windows, macOS, Linux |
| Empress Of The Deep | 2010 | Gogii Games | Microsoft Windows |
| Empress Of The Deep 2: Song Of The Blue Whale | 2007 | Gogii Games | Microsoft Windows |
| Empyreal | 2025 | — | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Encleverment Experiment | — | Mere Mortals, Blitz Games Studios | Xbox 360 |
| Endgame | 2002 | — | PlayStation 2 |
| Endgame: Syria | 2012 | — | web browser, Android |
| Enemy Engaged 2 | 2007 | Razorworks | Microsoft Windows, macOS |
| Enemy Engaged 2: Desert Operations | 2022 | — | Microsoft Windows |
| Enemy Engaged: Apache vs Havoc | 1998 | Razorworks | Microsoft Windows |
| Enemy Engaged: RAH-66 Comanche vs. KA-52 Hokum | — | Razorworks | Classic Mac OS, Microsoft Windows |
| Enemy Territory: Quake Wars | 2007 | Splash Damage | PlayStation 3, Microsoft Windows, macOS, Linux, Xbox 360 |
| Energy Airforce | — | Taito | PlayStation 2 |
| Enforcer: Police Crime Action | 2014 | — | Microsoft Windows, macOS |
| England Exchange | 2017 | — | Microsoft Windows, macOS, Linux |
| England International Football | 2004 | Codemasters | PlayStation 2, Xbox |
| English Country Tune | 2011 | Increpare games | Microsoft Windows, macOS, Linux, iOS |
| Enigma Force | 1985 | Aackosoft | Commodore 64 |
| Enslaved: Odyssey to the West | 2010 | Ninja Theory | PlayStation 3, Microsoft Windows, Xbox 360 |
| Enter the Dominatrix | 2013 | Volition | Microsoft Windows, Linux |
| Entombed | 1985 | Ultimate Play the Game | Commodore 64 |
| Entropy | — | — | Microsoft Windows |
| EOE: Eve of Extinction | 2002 | Yuke's | PlayStation 2 |
| Epic | 1992 | Digital Image Design | DOS |
| Epic Chef | 2021 | Infinigon Games | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, Xbox Series X and Series S |
| Epic Mickey 2: The Power of Two | 2012 | Junction Point Studios, Blitz Games Studios, Heavy Iron Studios | PlayStation 3, Microsoft Windows, PlayStation Vita, Xbox 360, Wii U, Wii |
| Equinox | 1993 | Software Creations | Super Nintendo Entertainment System |
| Equinox | 1986 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Erica | 2019 | — | Microsoft Windows, PlayStation 4 |
| Escape | 1982 | Malcolm Evans | ZX Spectrum, Commodore 64 |
| Escape Dead Island | 2014 | Fatshark | Microsoft Windows |
| Escape from Singe's Castle | 1987 | — | Classic Mac OS, DOS, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Escape from the Planet of the Robot Monsters | 1989 | Atari Games | Commodore Amiga, SAM Coupé, DOS, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Escape The Lost Kingdom: The Forgotten Pharaoh | 2010 | Gogii Games | Microsoft Windows |
| Escape The Museum | 2008 | Gogii Games | Microsoft Windows |
| Eskimo Eddie | 2023 | Ocean Software | Microsoft Windows, ZX Spectrum, Commodore 64 |
| ESPER | 2018 | Coatsink | Microsoft Windows |
| Eternal Threads | 2022 | Cosmonaut Studios | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Eternity's Child | 2008 | SilverSphereStudios, Luc Bernard | Microsoft Windows, Wii |
| Ether One | 2014 | White Paper Games | Microsoft Windows, PlayStation 4 |
| Etherlords | 2001 | Nival | Microsoft Windows |
| Etherlords II | 2003 | Nival | Microsoft Windows |
| Eufloria | 2009 | — | PlayStation 3, Microsoft Windows, PlayStation Vita, Linux, iOS, Android |
| Eureka! | 1984 | Ian Livingstone | ZX Spectrum, Commodore 64 |
| Euro Fishing | 2015 | Dovetail Games | Microsoft Windows, PlayStation 4 |
| Eurofighter Typhoon | 2001 | Digital Image Design | Microsoft Windows |
| Europa | 2024 | — | Microsoft Windows, Linux |
| Europa Universalis | 2000 | Paradox Interactive, Development Studio | Commodore Amiga, Microsoft Windows |
| Europa Universalis II | 2001 | Development Studio | Classic Mac OS, Microsoft Windows, macOS |
| Europa Universalis: Crown of the North | 2000 | Paradox Interactive | Microsoft Windows |
| European Champions | 1993 | — | Commodore Amiga, Atari ST |
| European Championship 1992 | 1992 | Tecmo | Commodore Amiga, DOS, Atari ST |
| European Club Soccer | 1993 | Krisalis Software | Sega Genesis/Mega Drive |
| European Ship Simulator | 2016 | — | Microsoft Windows, macOS |
| European Soccer Challenge | — | — | Commodore Amiga, ZX Spectrum, Amstrad CPC |
| European Superleague | 1990 | — | DOS, ZX Spectrum, Amstrad CPC |
| Evel Knievel | 1999 | Rockstar Lincoln | Game Boy Color |
| Evening Star | 1987 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Everest Ascent | 1983 | Richard Shepherd Software | ZX Spectrum, Commodore 64 |
| Evergate | 2020 | Stone Lantern Games | Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Evergate: Ki's Awakening | 2020 | Stone Lantern Games | Microsoft Windows |
| Eversion | 2008 | Zaratustra Productions | Microsoft Windows, macOS, Linux |
| Everwild | — | Rare Ltd. | Microsoft Windows, Xbox Series X and Series S |
| Everybody Dance | 2011 | London Studio | PlayStation 3 |
| Everybody's Gone to the Rapture | 2015 | The Chinese Room | Microsoft Windows, PlayStation 4 |
| Everyone Sing | 2012 | Gusto Games | PlayStation 3, Xbox 360, Wii |
| Everyone's A Wally | 1985 | Mikro-Gen | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Everything is Peachy | 2016 | — | Microsoft Windows |
| Evil Dead: A Fistful of Boomstick | 2003 | VIS Entertainment | PlayStation 2, Xbox |
| Evil Genius | 2004 | Elixir Studios | Microsoft Windows |
| Evil Genius 2: World Domination | 2021 | Rebellion Developments | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Evolva | 2000 | — | Microsoft Windows |
| Excalibur 2555 AD | 1997 | — | Microsoft Windows |
| EXceed 3rd - Jade Penetrate Black Package | 2012 | — | Microsoft Windows |
| Exhibition of Speed | 2001 | Titus Interactive | Dreamcast |
| Exile | 1988 | — | Commodore Amiga, Acorn Electron, Atari ST, Amiga CD32, BBC Micro, Commodore 64 |
| Exo One | 2021 | Exbleative | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Exo Rally Championship | 2026 | Exbleative | Microsoft Windows |
| Exodus from the Earth | 2007 | Parallax Arts Studio | Microsoft Windows |
| Exolon | 1987 | Dragonware, Linel | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Expelled! | 2025 | Inkle | Microsoft Windows, macOS, Nintendo Switch, iOS |
| Explodemon | 2011 | Curve Games | PlayStation 3, Microsoft Windows |
| Extase | 1990 | Cryo Interactive | DOS |
| Extractors | — | — | DOS |
| Extreme Exorcism | 2015 | — | Microsoft Windows, macOS, PlayStation 4, Wii U |
| Extreme-G | 1997 | Acclaim Studios London | Nintendo 64 |
| Extreme-G 2 | 1998 | Acclaim Studios London | Microsoft Windows, Nintendo 64 |
| Extreme-G 3 | 2001 | Acclaim Studios London | PlayStation 2, Nintendo GameCube |
| Eye of Horus | 1989 | Denton Designs | Commodore Amiga, DOS, Atari ST, Commodore 64 |
| EyePet | 2009 | London Studio | PlayStation 3, PlayStation Portable |
| EyePet & Friends | 2011 | London Studio | PlayStation 3 |
| EyeToy: Chat | 2005 | London Studio | PlayStation 2 |
| EyeToy: Groove | 2003 | London Studio | PlayStation 2 |
| EyeToy: Kinetic | 2005 | London Studio | PlayStation 2 |
| EyeToy: Operation Spy | 2005 | London Studio | PlayStation 2 |
| EyeToy: Play | 2003 | London Studio | PlayStation 2 |
| EyeToy: Play 2 | 2004 | London Studio | PlayStation 2 |
| EyeToy: Play 3 | 2005 | London Studio | PlayStation 2 |