| S&box | 2026 | Facepunch Studios | Microsoft Windows, Linux |
| S.C.A.R.S. | 1998 | Vivid Image | PlayStation, Microsoft Windows, Nintendo 64 |
| S.T.A.L.K.E.R.: Clear Sky | 2008 | GSC Game World | Microsoft Windows |
| S.T.A.L.K.E.R.: Shadow of Chernobyl | 2007 | GSC Game World | Microsoft Windows |
| Sable | 2021 | Shedworks | Xbox One, Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Saboteur | 1985 | — | Microsoft Windows, macOS, Nintendo Switch, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Saboteur II: Avenging Angel | 1987 | — | Microsoft Windows, DOS, Nintendo Switch, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Sabre Team | 1992 | Krisalis Software | Commodore Amiga, Microsoft Windows, DOS, Atari ST, Amiga CD32 |
| Sabre Wulf | 2004 | Rare Ltd. | Game Boy Advance |
| Sabre Wulf | 1984 | Ultimate Play the Game, Stamper brothers | ZX Spectrum, Amstrad CPC, BBC Micro, Commodore 64 |
| Sackboy: A Big Adventure | 2020 | Sumo Digital | Microsoft Windows, PlayStation 4, PlayStation 5 |
| Sacred 3 | 2014 | Keen Games | PlayStation 3, Microsoft Windows, PlayStation Vita, Xbox 360 |
| Sacred Citadel | 2013 | Southend Interactive | Microsoft Windows |
| Sai Combat | 1986 | — | ZX Spectrum, Amstrad CPC |
| Saints Row | 2021 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row IV | 2013 | Volition | PlayStation 3, Xbox One, Microsoft Windows, Nintendo Switch, Linux, Xbox 360, PlayStation 4 |
| Saints Row IV: Re-Elected | 2015 | Volition | Microsoft Windows, Linux, PlayStation 4, PlayStation 5 |
| Saints Row: Criminal Customs Editions | 2022 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row: Gat out of Hell | 2015 | Volition, High Voltage Software | PlayStation 3, Xbox One, Microsoft Windows, Linux, Xbox 360, PlayStation 4 |
| Saints Row: Gold Edition | 2022 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row: Legacy Edition | 2022 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row: Notorious Edition | 2022 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row: Platinum Edition | 2022 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row: Santo Ileso Pack | 2022 | Volition | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Saints Row: The Third Season Pass DLC Pack | 2011 | Volition | PlayStation 3, Microsoft Windows, Linux, Xbox 360 |
| Sakura Day 2 Mahjong | 2016 | Creobit | Microsoft Windows, macOS |
| Sakura Day Mahjong | 2015 | Creobit | Microsoft Windows, macOS |
| Sakura Spirit | 2014 | Winged Cloud | Microsoft Windows, macOS, Linux |
| Salt Lake 2002 | 2002 | Attention to Detail | PlayStation 2, Microsoft Windows, Game Boy Advance |
| Samantha Fox Strip Poker | 1986 | — | ZX Spectrum, MSX, Commodore 64 |
| Sampras Tennis 96 | 1995 | Codemasters | Sega Genesis/Mega Drive |
| Samurai Jack: The Amulet of Time | 2003 | — | Game Boy Advance |
| San Francisco Rush: Extreme Racing | 1997 | Atari Games, Midway Games, Climax Studios | PlayStation, PlayStation 2, Xbox, Microsoft Windows, Nintendo GameCube, Nintendo 64, arcade video game machine |
| Santa's Toy Factory Nonograms | 2020 | Somer Games | Microsoft Windows |
| Sanvein | 2000 | Success | PlayStation |
| Sanxion | 1986 | Thalamus Ltd | ZX Spectrum, Commodore 64 |
| SAS: Anti Terror Force | 2005 | Davilex Games, Atomic Planet Entertainment | PlayStation 2, Microsoft Windows |
| Savage | 1988 | Acclaim Studios London | Microsoft Windows, DOS, ZX Spectrum, Linux, Amstrad CPC, Commodore 64 |
| Savage Moon | 2008 | — | PlayStation 3 |
| Savage Pond | 1983 | — | Acorn Electron, Commodore 64 |
| Savoir-Faire | 2002 | — | — |
| Scania Truck Driving Simulator | 2012 | SCS Software | Microsoft Windows, macOS |
| Scanner Sombre | 2017 | Introversion Software | Microsoft Windows, macOS |
| Scapeghost | 1989 | Level 9 Computing | Commodore Amiga, DOS, ZX Spectrum, Amstrad CPC, Amstrad PCW, Atari ST, BBC Micro, Commodore 64 |
| Scarabaeus | 1985 | Andromeda Software | Commodore 64 |
| Scathe | 2022 | DAMAGE STATE | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Scene It?: The Simpsons | 2009 | Screenlife Games | DVD player |
| Schizofrenia | 1985 | — | ZX Spectrum, Commodore 64 |
| School Days | 2023 | MDickie Limited | Microsoft Windows, iOS, Android |
| Science Horizons Survival | 1984 | — | ZX Spectrum |
| Scooby-Doo | 1986 | Gargoyle Games | ZX Spectrum, Amstrad CPC |
| Scooby-Doo and Scrappy-Doo | 1991 | — | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Scooby-Doo and the Cyber Chase | 2001 | Art Co., Ltd | Game Boy Advance |
| Scooby-Doo Mystery | 1995 | Argonaut Games | Super Nintendo Entertainment System |
| Scooby-Doo Mystery | 1995 | Argonaut Games | Sega Genesis/Mega Drive, Super Nintendo Entertainment System |
| Scorched 3D | 2001 | — | Microsoft Windows, macOS, Linux |
| Scorched Planet | 1996 | Criterion Games | Microsoft Windows |
| Score! Classic Goals | 2012 | — | iOS, Android |
| Score! Hero | 2015 | First Touch Games | iOS, iPadOS, Android |
| Score! Hero 2 | 2021 | First Touch Games | iOS, iPadOS, Android |
| Score! World Goals | — | First Touch Games | Microsoft Windows, iOS, Android |
| Scourge of War: Waterloo | 2015 | NorbSoftDev | Microsoft Windows |
| Scrabble | 2009 | Electronic Arts, Stainless Games | Nintendo DS, PlayStation Portable |
| Scrabble | 1988 | — | Commodore Amiga, Classic Mac OS, iOS |
| Scram Kitty and his Buddy on Rails | 2014 | Dakko Dakko | Wii U |
| Scram Kitty DX | 2015 | Dakko Dakko | PlayStation Vita, PlayStation 4 |
| Screamer | 1995 | Milestone S.r.l. | Microsoft Windows, macOS, DOS, Linux |
| Screamer 2 | 1996 | Milestone S.r.l. | Microsoft Windows, macOS, Linux |
| Screamer Rally | 1997 | Milestone S.r.l. | Microsoft Windows, DOS |
| Screamride | 2015 | Frontier Developments | Xbox One |
| Scribble | 2016 | Bear Box Media | Wii U |
| Scuba Dive | 1983 | — | ZX Spectrum, Commodore 64 |
| Scud: The Disposable Assassin | 1997 | — | Sega Saturn |
| SCUM | 2025 | Croteam, Gamepires | Microsoft Windows |
| Sea Monsters: A Prehistoric Adventure | 2007 | Atomic Planet Entertainment | Wii |
| Sea of Thieves | 2018 | Rare Ltd. | Xbox One, Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Seabase Delta | 1986 | — | ZX Spectrum, Amstrad CPC |
| Seas of Blood | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Seashell | 2022 | High Tea Frog | Microsoft Windows, Nintendo Switch |
| Season of Infamy | 2015 | Rocksteady Studios | Xbox One, Microsoft Windows, PlayStation 4 |
| SeaWorld Adventure Parks Tycoon | 2003 | DR Studios | Microsoft Windows |
| Second Samurai | 1993 | — | Sega Genesis/Mega Drive, Microsoft Windows |
| Second Sight | 2004 | Crytek UK | PlayStation 2, Xbox, Microsoft Windows, Nintendo GameCube |
| Secret Files 2: Puritas Cordis | 2009 | Animation Arts | Microsoft Windows, Nintendo DS, Nintendo Switch, iOS, Wii, Android |
| Secret Files 3 | 2012 | Animation Arts | Microsoft Windows, iOS, Android |
| Secret Files: Sam Peters | 2014 | Animation Arts | Microsoft Windows, iOS, Android |
| Sega Arcade Gallery | — | Sega | Game Boy Advance |
| Sega Chess | 1991 | Acclaim Studios London | Sega Master System |
| Sega Mega Drive Classic Collection | 2010 | Sega | Xbox One, Microsoft Windows, macOS, Nintendo Switch, Linux, PlayStation 4 |
| Sega Rally 3 | 2008 | Sega Racing Studio | arcade video game machine, Xbox 360 |
| Sega Rally Revo | 2007 | Sega Racing Studio | PlayStation 3, Microsoft Windows, PlayStation Portable, Xbox 360 |
| Sega Superstars Tennis | 2008 | Sumo Digital | PlayStation 2, PlayStation 3, macOS, Nintendo DS, Xbox 360, Wii |
| Seiddab Trilogy | — | Graftgold | ZX Spectrum |
| Selfie : Sisters of the Amniotic Lens | 2015 | — | Microsoft Windows |
| Sengoku Jidai: Shadow of the Shogun | 2016 | Byzantine Games | Microsoft Windows |
| Sensible Golf | 1995 | Sensible Software | Commodore Amiga, Microsoft Windows, DOS |
| Sensible Soccer | 1992 | Sensible Software | Commodore Amiga, Sega Genesis/Mega Drive, DOS, Super Nintendo Entertainment System, Acorn Archimedes, Atari ST, Game Gear |
| Sensible Soccer 2006 | 2006 | Kuju Ltd. | PlayStation 2, Xbox, Microsoft Windows |
| Sensible Train Spotting | 1995 | Sensible Software | Commodore Amiga |
| Sensible World of Soccer | 1994 | Sensible Software | DOS |
| Sentient | 1997 | SCE Studio Liverpool | PlayStation, Microsoft Windows |
| Sentinel 3: Homeworld | 2010 | — | Microsoft Windows |
| Sentinel Returns | 1998 | — | PlayStation, Microsoft Windows |
| Senua | 2027 | Ninja Theory | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Senua's Saga: Hellblade II | 2024 | Ninja Theory | Microsoft Windows, Xbox Series X and Series S |
| Serial Cleaner | 2017 | Draw Distance | Xbox One, Microsoft Windows, macOS, Nintendo Switch, Linux, iOS, PlayStation 4 |
| Serious Sam Advance | 2004 | Climax Studios | Game Boy Advance |
| Serious Sam: Next Encounter | 2004 | Climax Studios | PlayStation 2, Nintendo GameCube |
| Serpent | 1990 | Kaga Create | Game Boy |
| Sesame Street Letters | 1989 | Rare Ltd. | Nintendo Entertainment System |
| Sesame Street: A-B-C/1-2-3 | 1991 | Rare Ltd. | Nintendo Entertainment System |
| Sesame Street: Friends & Fun | 2026 | Infinigon Games | Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Sesame Street: Numbers Count | 1989 | Rare Ltd. | Nintendo Entertainment System |
| Severance: Blade of Darkness | 2001 | MercurySteam | Microsoft Windows |
| Seymour Goes to Hollywood | — | Big Red Software | Commodore Amiga, DOS, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Shadow Empire | 2020 | VR Designs | Microsoft Windows |
| Shadow Fighter | 1994 | — | Amiga 1200, Amiga CD32 |
| Shadow Man | 1999 | Acclaim Studios Teesside | PlayStation, Microsoft Windows, macOS, Dreamcast, Nintendo 64 |
| Shadow Man: 2econd Coming | 2002 | Acclaim Studios Teesside | PlayStation 2 |
| Shadow Master | 1997 | — | PlayStation, Microsoft Windows |
| Shadow of the Beast | 2016 | — | PlayStation 4 |
| Shadow of the Beast | 1989 | Ubisoft Reflections | Commodore Amiga, TurboGrafx-16, Sega Genesis/Mega Drive, Super Nintendo Entertainment System, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Shadow of the Beast II | 1990 | Ubisoft Reflections | Commodore Amiga, Sega Genesis/Mega Drive, Atari ST |
| Shadow of the Beast III | 1992 | Ubisoft Reflections | Commodore Amiga |
| Shadow Sorcerer | 1991 | U.S. Gold | Commodore Amiga, DOS, Atari ST |
| Shadowfire | 1985 | Beyond Software, Denton Designs | ZX Spectrum, Commodore 64 |
| Shadowgrounds | 2005 | Frozenbyte | Microsoft Windows, macOS, Linux |
| Shadowgrounds: Survivor | 2009 | Frozenbyte | Microsoft Windows, macOS, Linux |
| Shadowhand | 2017 | Grey Alien Games | Microsoft Windows, macOS |
| Shadowlands | 1992 | — | DOS |
| Shadows of Doubt | 2024 | ColePowered Games | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Shadows: Price For Our Sins | 2021 | Creobit | Microsoft Windows |
| Shaken but Not Stirred | 1982 | — | ZX Spectrum |
| Shannon Tweed's Attack Of The Groupies | 2014 | Gogii Games | Microsoft Windows |
| Sheep | 2000 | Mind's Eye Productions | PlayStation, Microsoft Windows, macOS, Game Boy Advance |
| Sheep in Space | 1984 | Jeff Minter | Commodore 64 |
| Shellshock | 1996 | Core Design | PlayStation, DOS, Sega Saturn |
| Shellshock 2: Blood Trails | 2009 | Rebellion Developments | PlayStation 3, Microsoft Windows, Xbox 360 |
| Shellshock: Nam '67 | 2004 | Square Enix, Guerrilla Games | PlayStation 2, Xbox, Microsoft Windows |
| Sheltered | 2016 | Team17 | Xbox One, Microsoft Windows, macOS, Nintendo Switch, Linux, iOS, PlayStation 4, Android |
| Sheltered 2 | 2021 | — | Microsoft Windows |
| Shenmue III | 2019 | — | Nintendo Switch 2, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Shift 2 Unleashed | 2011 | Slightly Mad Studios | PlayStation 3, Microsoft Windows, PlayStation Portable, Xbox 360, iOS |
| Shift at Midnight | 2026 | — | Microsoft Windows |
| Shin Megami Tensei IV | 2013 | Atlus | Nintendo 3DS |
| Shin Megami Tensei IV: Apocalypse | 2016 | Atlus | Nintendo 3DS |
| Ship of Fools | 2022 | Fika Productions | Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| ShockRods | 2019 | Stainless Games | Microsoft Windows |
| Shockway Rider | 1987 | — | Amstrad CPC |
| Shogun: Total War | 2000 | Creative Assembly | Microsoft Windows |
| Shooty Fruity | 2018 | — | Microsoft Windows, PlayStation 4 |
| Shoppe Keep | 2016 | Arvydas Žemaitis | Xbox One, Microsoft Windows, macOS, Linux, PlayStation 4 |
| Shoppe Keep 2 | 2019 | — | Microsoft Windows |
| Short Circuit | 1987 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Shotest Shogi | 2008 | — | Microsoft Windows |
| Shox | 2002 | Electronic Arts | PlayStation 2 |
| Shrek: Treasure Hunt | 2002 | The Code Monkeys | PlayStation |
| Shu | 2016 | — | Microsoft Windows, Nintendo Switch |
| Shuten Order | 2025 | Too Kyo Games, Neilo | Nintendo Switch 2, Microsoft Windows, Nintendo Switch |
| Shuttle | 1992 | Vektor Grafix | DOS |
| Sidewize | 1987 | Odin Computer Graphics | ZX Spectrum, Commodore 64 |
| Signet City | — | Jump Over the Age | Microsoft Windows |
| Silent Hill: Origins | 2007 | Climax Studios | PlayStation 2, PlayStation Portable |
| Silent Hill: Shattered Memories | 2009 | Climax Studios | PlayStation 2, PlayStation Portable, Wii |
| Silent Hill: Townfall | 2026 | Annapurna Interactive, Screen Burn | Microsoft Windows, PlayStation 5 |
| Silicon Dreams | 1986 | Level 9 Computing | Classic Mac OS, DOS, ZX Spectrum, Amstrad CPC, Amstrad PCW, MSX, Commodore 64 |
| Silly Polly Beast | 2025 | — | Microsoft Windows |
| Silt | 2022 | Spiral Circus | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Silver | 1999 | — | Classic Mac OS, Microsoft Windows, macOS, Dreamcast, Linux |
| Silver Pines | 2026 | — | Nintendo Switch 2, Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Silver Surfer | 1990 | Software Creations | Nintendo Entertainment System |
| Silverball | 1993 | Digital Extremes | MS-DOS |
| SilverLoad | 1995 | — | PlayStation, DOS |
| Sim Brick | 1991 | Sensible Software | Commodore Amiga |
| Sim Junta | 2015 | — | Microsoft Windows |
| SimCity 2000 | 1993 | Maxis, Full Fat | Commodore Amiga, PlayStation, Classic Mac OS, Microsoft Windows, macOS, DOS, Super Nintendo Entertainment System, Nintendo 64, Game Boy Advance, Sega Saturn, Windows Mobile, Acorn Archimedes+2 |
| SimIsle | 1995 | Intelligent Games | Classic Mac OS, Microsoft Windows, DOS |
| Simon Tatham's Portable Puzzle Collection | — | Simon Tatham | — |
| Simon the Sorcerer | 1993 | Adventure Soft | Microsoft Windows, DOS, Acorn Archimedes, Amiga 1200, iOS, Android |
| Simon the Sorcerer 3D | 2002 | Headfirst Productions | Microsoft Windows |
| Simon the Sorcerer II: The Lion, the Wizard and the Wardrobe | 1995 | Adventure Soft | Commodore Amiga, Classic Mac OS, Microsoft Windows, DOS, iOS |
| Simon the Sorcerer's Pinball | 1998 | Adventure Soft | Microsoft Windows |
| SimSig | — | — | Microsoft Windows |
| Simulcra | 1990 | — | Commodore Amiga |
| Sinbad and the Golden Ship | 1986 | — | ZX Spectrum |
| Sing Party | 2012 | Ubisoft Leamington | Wii U |
| Singles 2: Triple Trouble | 2005 | Rotobee | Microsoft Windows |
| Singles: Flirt Up Your Life | 2004 | Rotobee | Microsoft Windows |
| SingStar | 2007 | London Studio | PlayStation 3 |
| SingStar '90s | — | Sony Interactive Entertainment Europe | PlayStation 2 |
| SingStar Dance | 2010 | London Studio | PlayStation 3 |
| SingStar Guitar | 2010 | London Studio | PlayStation 3 |
| SingStar Queen | 2009 | London Studio | PlayStation 2, PlayStation 3 |
| SingStar Take That | 2009 | London Studio | PlayStation 2 |
| SingStar The Dome | — | — | PlayStation 2 |
| SingStar: ABBA | 2008 | London Studio | PlayStation 2, PlayStation 3 |
| Sink or Swim | 1993 | Eutechnyx | Sega Genesis/Mega Drive, DOS, Super Nintendo Entertainment System |
| Sir Lancelot | 1984 | — | ZX Spectrum, Amstrad CPC |
| Sir, You Are Being Hunted | 2013 | Big Robot | Microsoft Windows, macOS, Linux |
| Siren City | 1983 | — | Commodore 64 |
| Sixty Words by POWGI | 2022 | Lightwood Games | Xbox One, PlayStation 4, Xbox Series X and Series S |
| Skatin' USA | 1989 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Skidmarks | 1993 | Acid Software | Commodore Amiga |
| Skidz | 1990 | Core Design | Commodore Amiga, Atari ST |
| Skinwalker | 2026 | — | Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Skipper & Skeeto: Tales from Paradise Park | 1996 | Ivanoff Interactive | Microsoft Windows |
| Skipper & Skeeto: The Great Treasure Hunt | 1997 | Ivanoff Interactive | Microsoft Windows |
| Skool Daze | 1984 | — | ZX Spectrum, Commodore 64 |
| Skool Daze Reskooled | 2018 | — | Microsoft Windows, macOS |
| Skramble | 1983 | Aackosoft, Microdeal | MSX |
| Skull & Crossbones | 1987 | Atari Games | Nintendo Entertainment System, arcade video game machine, Commodore 64 |
| Skull Caps | 1998 | — | Microsoft Windows |
| Sky Oceans: Wings for Hire | 2024 | Octeto Studios | Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Sky Runner | 1986 | — | DOS, ZX Spectrum |
| Sky Shadow | 1990 | Patrick Buckland | Classic Mac OS, Mac operating system |
| Sky Sports Football Quiz Season 02 | 2002 | Hothouse Creations | PlayStation |
| Sky Surfer | — | Toka | PlayStation 2 |
| Skyhammer | 2000 | Rebellion Developments | Atari Jaguar |
| Skyscrappers | 2015 | Ground Shatter | Microsoft Windows, macOS, Nintendo Switch, Linux |
| Slalom | 1987 | Rare Ltd. | Nintendo VS. System, Nintendo Entertainment System |
| Slave of God | 2012 | Increpare games | Microsoft Windows, macOS |
| Slay | 1996 | — | Microsoft Windows, iOS, Android |
| Slayer | 1988 | — | Commodore Amiga |
| Slayers X: Terminal Aftermath: Vengance of the Slayer | 2023 | — | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Slaygon | 1988 | — | Commodore Amiga, Atari ST |
| Sleeping Dogs | 2012 | United Front Games | PlayStation 3, Xbox One, Microsoft Windows, macOS, Xbox 360, PlayStation 4 |
| Sleeping Dogs: Definitive Edition | 2014 | United Front Games, Feral Interactive | Xbox One, Microsoft Windows, macOS, PlayStation 4 |
| Sleepwalker | 1993 | Ocean Software | Microsoft Windows, DOS, Amiga 1200, Atari ST, Amiga CD32, Commodore 64 |
| Slightly Magic | 1991 | — | ZX Spectrum, Amstrad CPC, iOS, Android, Commodore 64 |
| Slipstream 5000 | 1995 | The Software Refinery | Microsoft Windows, macOS, DOS |
| Smart As | 2012 | Climax Studios | PlayStation Vita |
| Smart Bomb | 2005 | Core Design | PlayStation Portable |
| Smarties: Meltdown | 2006 | Europress | PlayStation 2 |
| Smash Up | 2016 | Nomad Games | Microsoft Windows |
| Smoke and Sacrifice | 2018 | — | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Smuggler's Run | 2000 | Rebellion Developments, Rockstar San Diego | PlayStation 2, Nintendo GameCube, Game Boy Advance |
| Snake Pass | 2017 | Sumo Digital | Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Snake Rattle 'n' Roll | 1990 | Rare Ltd. | Sega Genesis/Mega Drive, Nintendo Entertainment System |
| Snakes | 2005 | IOMO | N-Gage |
| Snapper | 1982 | — | BBC Micro |
| Sneak King | 2006 | Blitz Games | Xbox, Xbox 360 |
| Sneaky Snakes | — | Rare Ltd. | Game Boy |
| Sneeze | 2009 | — | — |
| Sniper Dan | 2026 | — | Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Sniper Elite | 2005 | Rebellion Developments | PlayStation 2, Xbox, Microsoft Windows, Wii |
| Sniper Elite 4 | 2017 | Rebellion Developments | Xbox One, Microsoft Windows, macOS, Nintendo Switch, iOS, PlayStation 4, iPadOS |
| Sniper Elite 5 | 2022 | Rebellion Developments | Xbox One, Microsoft Windows, macOS, iOS, PlayStation 4, PlayStation 5, iPadOS, Xbox Series X and Series S |
| Sniper Elite 5 Deluxe Edition | 2022 | Rebellion Developments | Xbox One, Microsoft Windows, Xbox Series X and Series S |
| Sniper Elite III | 2014 | Rebellion Developments | PlayStation 3, Xbox One, Microsoft Windows, Xbox 360, PlayStation 4 |
| Sniper Elite V2 | 2012 | Rebellion Developments | PlayStation 3, Microsoft Windows, Xbox 360, Wii U |
| Sniper Elite V2 Remastered | 2019 | Rebellion Developments | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Sniper Elite VR | 2021 | Rebellion Developments | Microsoft Windows, PlayStation 4 |
| Sniper Elite: Nazi Zombie Army | 2013 | Rebellion Developments | Microsoft Windows |
| Sniper Elite: Nazi Zombie Army 2 | 2013 | Rebellion Developments | Microsoft Windows |
| Sniper Elite: Resistance | 2025 | Rebellion Developments | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Sniper: Path of Vengeance | 2002 | Mirage Media S.C. | Microsoft Windows |
| Snipperclips | 2017 | SFB Games | Nintendo Switch |
| Snooker | 1983 | — | ZX Spectrum, Commodore VIC-20 |
| Snooker 19 | 2019 | Lab42 | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Snoopy Coaster | 2013 | CGMatic | iOS, Android |
| Snoopy Tennis | 2001 | — | Game Boy Color |
| Snow White and the 7 Clever Boys | 2006 | — | PlayStation 2 |
| Snow White: Happily Ever After | 1994 | ASC Games | Super Nintendo Entertainment System |
| Snowboarding | 2000 | Atelier Double | PlayStation |
| So Blonde | 2008 | Wizarbox | Microsoft Windows, Nintendo DS, Wii |
| Soccer Kid | 1993 | Krisalis Software | PlayStation, Microsoft Windows, DOS, Super Nintendo Entertainment System, Game Boy Advance, 3DO, Amiga 1200 |
| Soccer Manager 2024 | 2023 | — | iOS, Android |
| Soccer Mania | 2002 | Silicon Dreams Studios | PlayStation 2, Microsoft Windows, Game Boy Advance |
| Soccer Story | 2022 | Panic Barn | Xbox One, Microsoft Windows, PlayStation 4, Xbox Series X and Series S |
| Soda Constructor | 2000 | — | Java virtual machine |
| Soft & Cuddly | 1987 | — | ZX Spectrum |
| Soft Aid | 1985 | — | ZX Spectrum |
| Software Star | 1985 | Addictive Games | ZX Spectrum, Amstrad CPC |
| Sokobond | 2014 | — | Microsoft Windows, macOS, Nintendo Switch |
| Solar Flux | 2013 | Firebrand Games | Microsoft Windows, macOS, Nintendo Switch, Linux |
| Solar Jetman | 1990 | Zippo Games | Nintendo Entertainment System, Commodore 64 |
| Soldiers: Heroes of World War II | 2004 | Best Way | Microsoft Windows |
| Solid Ice | 1996 | Strategy First | DOS |
| Solitaire Beach Season | 2016 | Creobit | Microsoft Windows |
| Solitaire Beach Season 2 | 2022 | Creobit | Microsoft Windows |
| Solitaire Beach Season 3 | 2022 | Creobit | Microsoft Windows, iOS |
| Solitaire Beach Season A Vacation Time | 2022 | Creobit | Microsoft Windows |
| Solitaire Beach Season Sounds of Waves | 2020 | Somer Games | Microsoft Windows |
| Solitaire Bonbon | 2022 | Somer Games | Microsoft Windows |
| Solitaire Christmas. Match 2 Cards | 2015 | Creobit | Microsoft Windows |
| Solitaire Game Christmas | 2022 | Creobit | Microsoft Windows |
| Solitaire Game Halloween | 2019 | Creobit | Microsoft Windows, macOS |
| Solitaire Game Halloween 2 | 2021 | Creobit | Microsoft Windows |
| Solitaire Halloween Story | 2020 | Creobit | Microsoft Windows |
| Solitaire Jack Frost Winter Adventures | 2019 | Somer Games | Microsoft Windows, macOS |
| Solitaire Jack Frost Winter Adventures 2 | 2021 | Somer Games | Microsoft Windows |
| Solitaire Jack Frost Winter Adventures 3 | 2022 | Somer Games | Microsoft Windows |
| Solitaire Legend of the Pirates | 2019 | Somer Games | Microsoft Windows, macOS, iOS |
| Solitaire Legend of the Pirates 2 | 2021 | Somer Games | Microsoft Windows |
| Solitaire Legend of the Pirates 3 | 2021 | Somer Games | Microsoft Windows |
| Solitaire Match 2 Cards. Thanksgiving Day | 2022 | Creobit | Microsoft Windows |
| Solitaire Match 2 Cards. Valentine's Day | 2019 | Creobit | Microsoft Windows, macOS |
| Solitaire TED and PET | 2021 | Somer Games | Microsoft Windows |
| Solitaire Victorian Picnic | 2019 | Big Up Studio | Microsoft Windows, macOS |
| Solitaire Victorian Picnic 2 | 2021 | Somer Games | Microsoft Windows |
| Solstice | 1990 | Software Creations | Nintendo Entertainment System |
| Somerville | 2022 | Jumpship | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Son of Blagger | 1983 | Antony Crowther | ZX Spectrum, Commodore 64 |
| Songbird Symphony | 2019 | — | Microsoft Windows, macOS, Nintendo Switch, PlayStation 4 |
| Sonic & All-Stars Racing Transformed | 2012 | Sumo Digital | PlayStation 3, Microsoft Windows, PlayStation Vita, Nintendo 3DS, Xbox 360, iOS, Wii U, Android |
| Sonic & Sega All-Stars Racing | 2010 | Sumo Digital | PlayStation 3, Microsoft Windows, macOS, Nintendo DS, Xbox 360, iOS, Wii, Android |
| Sonic 3D Blast | 1996 | Traveller's Tales | Sega Genesis/Mega Drive, Microsoft Windows, Sega Saturn |
| Sonic Classic Collection | 2010 | Creative Assembly | Nintendo DS |
| Sonic Dash | 2013 | Hardlight | Microsoft Windows, iOS, Windows Phone, Android |
| Sonic Dash 2: Sonic Boom | 2015 | Hardlight, Sumo Digital | iOS, Android |
| Sonic Dream Team | 2023 | Hardlight | macOS, tvOS, iOS, iPadOS |
| Sonic Jump | 2012 | Hardlight | iOS, Android |
| Sonic Jump Fever | 2014 | Hardlight | iOS, Android |
| Sonic R | 1997 | Traveller's Tales | Microsoft Windows, Sega Saturn |
| Sophie's World | 1997 | — | Classic Mac OS, Microsoft Windows |
| Sorcerer Lord | 1987 | Personal Software Services | Commodore Amiga, Microsoft Windows, DOS, ZX Spectrum, Linux, Amstrad CPC, Atari ST, Commodore 64 |
| Sorderon's Shadow: The Legend of Elindor | 1985 | Beyond Software | ZX Spectrum |
| Sorry We're Closed | 2024 | À la mode games | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Soul Axiom | 2016 | Wales Interactive | Xbox One, Microsoft Windows, macOS, Linux, PlayStation 4, Wii U |
| Soul Bubbles | 2008 | Mekensleep | Nintendo DS |
| Soul of a Robot | 1985 | — | ZX Spectrum, Amstrad CPC, MSX |
| Soul Reaver 2 | 2001 | Crystal Dynamics | PlayStation 2, Microsoft Windows |
| Soulbringer | 2000 | Suntendy Interactive Multimedia Co.,Ltd., Infogrames | Microsoft Windows |
| Soulstar | 1994 | Core Design | Sega CD/Mega CD, Sega Genesis/Mega Drive |
| South of the Circle | 2020 | State of Play | Xbox One, Microsoft Windows, macOS, Nintendo Switch, tvOS, iOS, PlayStation 4, iPadOS, Xbox Series X and Series S |
| South Park Let's Go Tower Defense Play! | 2009 | Doublesix | Xbox 360 |
| Southern Belle | 1985 | Hewson Consultants | ZX Spectrum, Amstrad CPC, Amstrad PCW, Commodore 64 |
| Southfield | 2024 | Radical Forge | Microsoft Windows |
| Sovereign Tower | 2026 | Wild Wits Games | Microsoft Windows, Linux |
| Space Ace | 1994 | Oxford Digital Enterprises Ltd | Super Nintendo Entertainment System |
| Space Ark | 2010 | Strawdog Studios | Microsoft Windows |
| Space Battle | 1987 | Digital Dreams | Commodore Amiga |
| Space Bucks | 1996 | Impressions Games | Microsoft Windows |
| Space Chef | 2025 | — | Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Space Colony | 2003 | Firefly Studios | Microsoft Windows, macOS |
| Space Crew | 2020 | Runner Duck | Microsoft Windows, macOS, Nintendo Switch, Linux, PlayStation 4 |
| Space Crusade | 1992 | Gremlin Interactive | Commodore Amiga, DOS, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Space Doubt | 1985 | — | Commodore 64 |
| Space Empires II | 1995 | Malfador Machinations | Microsoft Windows |
| Space Empires V | 2006 | Malfador Machinations | Microsoft Windows |
| Space Football: One on One | 1992 | Bits Studios | Super Nintendo Entertainment System |
| Space Funeral | 2010 | Stephen Gillmurphy | Microsoft Windows |
| Space Giraffe | 2007 | LLamasoft | Microsoft Windows |
| Space Haste 2 | 2022 | — | Microsoft Windows |
| Space Hulk: Vengeance of the Blood Angels | 1995 | — | PlayStation, Microsoft Windows, DOS, 3DO |
| Space Overlords | 2016 | 12 Hit Combo | Microsoft Windows, PlayStation Vita, PlayStation 4 |
| Space Rangers 2: Rise of the Dominators | 2004 | Elemental Games | Microsoft Windows |
| Space Station Silicon Valley | 1998 | Rockstar North | PlayStation, Nintendo 64 |
| Space Trash Scavenger | 2023 | SquarePlay Games | Microsoft Windows |
| Spaceplan | 2017 | — | Microsoft Windows, macOS, iOS, Android |
| Spare Parts | 2011 | Electronic Arts | PlayStation 3, Xbox 360 |
| Sparrow Solitaire | 2023 | — | Playdate |
| Spartan | 2004 | Slitherine Software UK Limited | Microsoft Windows |
| Spartan: Total Warrior | 2005 | Creative Assembly | PlayStation 2, Xbox, Nintendo GameCube |
| Special Forces | 1991 | Sleepless Knights | Commodore Amiga, DOS, Atari ST |
| Spectra | 2015 | — | Microsoft Windows, macOS, Linux |
| Spectrum Safari | 1983 | — | ZX Spectrum |
| Spectrum Voice Chess | 1982 | Aackosoft | ZX Spectrum |
| Speed Kills | 2014 | — | Microsoft Windows |
| Speed Kings | 2003 | Climax Studios | PlayStation 2, Xbox, Nintendo GameCube |
| Speedball | 2024 | Rebellion Developments | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Speedball | 1988 | The Bitmap Brothers | Commodore Amiga, PlayStation, Game Boy, Game Boy Advance, Acorn Archimedes, Xbox 360, Commodore 64 |
| Speedball 2100 | 2000 | The Bitmap Brothers | PlayStation |
| Speedball 2: Brutal Deluxe | 2007 | Empire Interactive | Commodore Amiga, Sega Genesis/Mega Drive, Xbox 360, Atari ST, Commodore 64 |
| Speedball 2: Brutal Deluxe | 1990 | The Bitmap Brothers | Commodore Amiga, Sega Master System, Acorn Archimedes, Amiga CD32, Commodore 64 |
| Speedboat Attack | 1997 | Criterion Games | Microsoft Windows |
| SpeedRage | 1996 | Hexerei Games | DOS |
| Speedy Gonzales: Los Gatos Bandidos | 1995 | Sunsoft | Super Nintendo Entertainment System |
| Spellbind | 2015 | — | Microsoft Windows |
| Spellbinder | 1987 | — | Acorn Electron |
| Spellbound | 1985 | David Jones | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Spellbound | 1984 | — | ZX Spectrum |
| Spellbound Dizzy | 1991 | Codemasters | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Spellcross | 1997 | Cauldron | DOS |
| Spelling Challenges and More! | 2007 | Supersonic Software | Nintendo DS |
| Spheres of Chaos | 1992 | — | Linux, Acorn Archimedes |
| Sphinx and the Cursed Mummy | 2003 | THQ Nordic, Eurocom | PlayStation 2, Xbox, Microsoft Windows, macOS, Nintendo GameCube, Java virtual machine, Nintendo Switch, Linux, PlayStation 4 |
| Spice World | 1998 | London Studio | PlayStation |
| Spider-Man 3: Invasion of the Spider-Slayers | 1993 | Bits Studios | Game Boy |
| Spider-Man and Captain America in Doctor Doom's Revenge | 1989 | Paragon Software | Commodore Amiga, DOS, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Spider-Man and the X-Men in Arcade's Revenge | 1993 | Software Creations | Sega Genesis/Mega Drive, Super Nintendo Entertainment System, Game Boy, Game Gear |
| Spider-Man and Venom: Maximum Carnage | 1994 | Software Creations | Sega Genesis/Mega Drive, Super Nintendo Entertainment System |
| Spider-Man: Return of the Sinister Six | 1992 | Bits Studios | Nintendo Entertainment System, Sega Master System, Game Gear |
| Spike in Transylvania | 1991 | — | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Spin Jam | 2000 | — | PlayStation, PlayStation 3, PlayStation Portable, PlayStation Vita |
| Spindizzy | 1986 | Electric Dreams Software | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Spindizzy Worlds | 1992 | — | Commodore Amiga, Super Nintendo Entertainment System, Atari ST |
| Spirit Guide Crucible | 2017 | IndieRevo | Microsoft Windows |
| Spirit of Excalibur | 1990 | Synergistic Software | Commodore Amiga, Apple IIGS, Classic Mac OS, DOS, Atari ST, CDTV |
| Spirit of Speed 1937 | 2000 | — | Dreamcast |
| Spirit of the Stones | 1984 | — | Commodore 64 |
| Spitfire '40 | 1985 | Aackosoft, Novotrade | ZX Spectrum, Atari 8-bit family, Amstrad CPC, Atari ST, BBC Micro, MSX, Commodore 64 |
| Spitting Image | 1989 | — | Commodore Amiga, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Splat! | 1983 | — | SAM Coupé, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Split Personalities | 1986 | — | ZX Spectrum, Amstrad CPC |
| Split/Second | 2010 | Black Rock Studio | PlayStation 3, Microsoft Windows, PlayStation Portable, Java virtual machine, Xbox 360, iOS |
| SpongeBob SquarePants: Creature from the Krusty Krab | 2006 | Blitz Games | PlayStation 2, Nintendo DS, Nintendo GameCube, Game Boy Advance, Wii |
| SpongeBob SquarePants: SuperSponge | 2001 | Climax Studios | PlayStation, Game Boy Advance |
| SpongeBob SquarePants: The Patrick Star Game | 2024 | PHL Collective | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| SpongeBob SquarePants: Underpants Slam | 2007 | Blitz Arcade | Xbox 360 |
| SpongeBob's Atlantis SquarePantis | 2007 | Blitz Games | PlayStation 2, Nintendo DS, Game Boy Advance, Wii |
| SpongeBob's Boating Bash | 2010 | Firebrand Games | Nintendo DS, Wii |
| SpongeBob's Surf & Skate Roadtrip | 2011 | Blitz Games | Nintendo DS, Xbox 360 |
| Spooked | 1989 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Spooks | 1985 | — | Commodore 64 |
| Spooky Bonus | 2013 | Grey Alien Games | Microsoft Windows, macOS |
| Spooky Mahjong | 2021 | — | Microsoft Windows |
| Spore | 1987 | — | ZX Spectrum, Commodore 64 |
| Sporting Triangles | — | — | ZX Spectrum, Amstrad CPC |
| Spot Goes To Hollywood | 1996 | Eurocom, Burst Studios | Sega Genesis/Mega Drive, PlayStation, Sega Saturn |
| Spot: The Cool Adventure | 1994 | Visual Concepts | Game Boy |
| Spot: The Video Game | 1990 | Visual Concepts, Virgin Interactive | DOS, Nintendo Entertainment System, Game Boy |
| Sprawl Zero | 2026 | — | Nintendo Switch 2, Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Spray Paint Simulator | 2025 | — | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Spring Bonus | 2017 | Grey Alien Games | Microsoft Windows, macOS |
| Spud! | 2015 | — | Microsoft Windows |
| Spy Hunter | 2012 | TT Fusion | PlayStation Vita, Nintendo 3DS |
| Spy Snatcher | — | — | ZX Spectrum, Amstrad CPC, Amstrad PCW |
| Spy Story. The Elusive Evidence | 2020 | Somer Games | Microsoft Windows |
| Spy vs. Spy | 1984 | Aackosoft, First Star Software | Commodore Amiga, PlayStation 2, Xbox, Nintendo Entertainment System, Game Boy, Game Boy Color, Sega Master System, ZX Spectrum, Acorn Electron, Amstrad CPC, iOS, Atari ST+2 |
| Spycat | 1988 | — | Acorn Electron |
| Spyder | 2020 | Sumo Digital | macOS, tvOS, iOS, iPadOS |
| Spyder: Agent 8 | 2027 | Sumo Digital | Nintendo Switch 2, Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Spyglass Board Games | 2007 | Strange Flavour | Xbox 360 |
| Spyro: A Hero's Tail | 2004 | Eurocom | PlayStation 2, Xbox, Nintendo GameCube |
| Squadron: Sky Guardians | 2017 | — | Microsoft Windows |
| SquareCells | 2015 | Matthew Brown | Microsoft Windows, macOS, Linux |
| Stack Light Rifle | — | — | ZX Spectrum |
| Stack-Up | 1991 | — | Commodore Amiga, DOS, ZX Spectrum, Atari 8-bit family, Atari ST, Commodore 64 |
| Star Citizen | — | Cloud Imperium Games | Microsoft Windows |
| Star Dynasties | 2021 | Pawley Games | Microsoft Windows |
| Star Fighter | 1995 | — | PlayStation, 3DO, Acorn Archimedes |
| Star Fox | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games | Super Nintendo Entertainment System, Super NES Classic Edition |
| Star Fox 2 | 2017 | Nintendo | Super Nintendo Entertainment System, Nintendo Switch, Super NES Classic Edition |
| Star Fox Adventures | 2002 | Rare Ltd. | Nintendo GameCube |
| Star Fox: Super Weekend | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games | Super Nintendo Entertainment System |
| Star Hammer: The Vanguard Prophecy | 2015 | Black Lab Games | Microsoft Windows, macOS, iOS, PlayStation 4 |
| Star Monkey | 2001 | Small Rockets | Microsoft Windows |
| Star Paws | 1987 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Star Trader | 1984 | — | ZX Spectrum, Commodore 64 |
| Star Trek | 1983 | Interceptor Micros | — |
| Star Trek Prodigy: Supernova | 2022 | Tessera Studios | PlayStation 3, Xbox One, Microsoft Windows, Game Boy, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Star Trek: Conquest | 2007 | 4J Studios | PlayStation, PlayStation 2, Wii |
| Star Trek: Encounters | 2006 | 4J Studios | PlayStation, PlayStation 2 |
| Star Trek: Invasion | 2000 | Warthog Games | PlayStation |
| Star Trek: Outposts Unknown | 2026 | — | Microsoft Windows, macOS |
| Star Trek: The Rebel Universe | 1987 | Simon & Schuster | DOS, Atari 2600, Atari ST, Commodore 64 |
| Star Wars | 1991 | Lucasfilm Games, Krome Studios Melbourne, NMS Software, Tiertex Design Studios | Nintendo Entertainment System, Game Boy, Sega Master System, Game Gear |
| Star Wars | 1983 | Atari, Inc., Vektor Grafix | Commodore Amiga, ColecoVision, DOS, arcade video game machine, Atari 2600, ZX Spectrum, Acorn Electron, Amstrad CPC, Atari ST, Atari 5200, BBC Micro, Commodore 64 |
| Star Wars Battlefront II | 2017 | Criterion Games, Motive Studio, DICE | Xbox One, Microsoft Windows, PlayStation 4 |
| Star Wars Battlefront: Elite Squadron | 2009 | Rebellion Developments, n-Space | Nintendo DS, PlayStation Portable |
| Star Wars Battlefront: Renegade Squadron | 2007 | Rebellion Developments | PlayStation Portable |
| Star Wars Episode I: Jedi Power Battles | 2000 | Lucasfilm Games | PlayStation, Dreamcast |
| Star Wars Episode I: Obi-Wan's Adventures | 2000 | HotGen | Game Boy Color |
| Star Wars Jedi: Fallen Order | 2019 | Criterion Games, Panic Button, Respawn Entertainment | Xbox One, Microsoft Windows, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Star Wars: Droids | 1988 | Binary Design | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Star Wars: Episode II – Attack of the Clones | 2002 | Lucasfilm Games | Game Boy Advance |
| Star Wars: Flight of the Falcon | 2003 | — | Game Boy Advance |
| Star Wars: Galactic Racer | 2026 | — | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Star Wars: Hunters | 2024 | BossAlien, NaturalMotion | Nintendo Switch, iOS, Android |
| Star Wars: Return of the Jedi | 1984 | Atari, Inc., Atari, Tengen | Commodore Amiga, DOS, arcade video game machine, ZX Spectrum, Amstrad CPC, Atari ST, BBC Micro, Commodore 64 |
| Star Wars: The Empire Strikes Back | 1985 | Atari Games, Vektor Grafix | Commodore Amiga, arcade video game machine, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Star Wreck | 1987 | Alternative Software | ZX Spectrum, Amstrad CPC |
| Star X | 2002 | Graphic State Games | Game Boy Advance |
| Starbound | 2016 | Chucklefish | Xbox One, Microsoft Windows, macOS, Linux, Xbox Series X and Series S |
| Starch | — | — | Acorn Archimedes |
| Starfox | 1987 | Realtime Games Software | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Stargate | 1994 | Acclaim Studios London | Sega Genesis/Mega Drive, Super Nintendo Entertainment System |
| Stargate: Timekeepers | 2024 | CreativeForge Games | Microsoft Windows |
| Starglider | 1986 | Argonaut Games | Commodore Amiga, DOS, ZX Spectrum, Amstrad CPC, Amstrad PCW, Atari ST, Commodore 64 |
| Starglider 2 | 1988 | Argonaut Games | Classic Mac OS, DOS, ZX Spectrum |
| Stargoose | 1988 | — | Commodore Amiga, DOS, Atari ST |
| Starlancer | 2000 | Digital Anvil | Microsoft Windows, Dreamcast |
| Starlord | 1993 | MicroProse | Microsoft Windows, DOS, Linux |
| Starquake | 1984 | Bubble Bus Software | DOS, ZX Spectrum, Amstrad CPC, Atari ST, MSX, Commodore 64 |
| Starring Charlie Chaplin | 1988 | Canvas Software | DOS, ZX Spectrum, Amstrad CPC |
| Stars! | 1995 | — | Microsoft Windows |
| Starscape | 2004 | Moonpod | Microsoft Windows |
| Starship Command | 1983 | — | BBC Micro |
| Starship Titanic | 1998 | Simon & Schuster, The Digital Village | Classic Mac OS, Microsoft Windows, macOS, Linux |
| Starship Troopers | 2005 | Strangelite | Microsoft Windows |
| Starship Troopers: Terran Command | 2022 | The Aristocrats | Microsoft Windows |
| Starship Troopers: Ultimate Bug War! | 2026 | Auroch Digital | Nintendo Switch 2, Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Starsky & Hutch | 2003 | Mind's Eye Productions | PlayStation 2, Xbox, Microsoft Windows, Nintendo GameCube, Game Boy Advance |
| Starstrike II | 1986 | — | Amstrad CPC |
| Start the Party! | 2010 | Supermassive Games | PlayStation 3 |
| Startenders: Intergalactic Bartending | 2024 | — | Microsoft Windows |
| Startopia | 2001 | Mucky Foot Productions | Microsoft Windows |
| State of Emergency | 2002 | VIS Entertainment | PlayStation 2, Xbox, Microsoft Windows |
| State of Emergency 2 | 2006 | DC Studios | PlayStation 2 |
| StateShift | 2007 | Engine Software | PlayStation Portable |
| STATIC: Investigator Training | 2009 | — | Microsoft Windows |
| Stealth Bastard | 2011 | Curve Games | Microsoft Windows, macOS, Linux, iOS, PlayStation 4, Android |
| Stealth Inc. 2: A Game of Clones | 2015 | Curve Games | Microsoft Windows, PlayStation Vita, Wii U |
| Steam Heroes | 2014 | — | Microsoft Windows |
| Steam to Electric | 2026 | Galaxy Grove | Microsoft Windows |
| Steel | — | — | Commodore Amiga |
| Steel Horizon | 2007 | Climax Studios | Nintendo DS, PlayStation Portable |
| Steg | 1992 | Big Red Software | DOS, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Steins;Gate 0 | 2015 | Mages | PlayStation 3, Microsoft Windows, PlayStation Vita, Nintendo Switch, PlayStation 4 |
| Stellar Blade | 2024 | PlayStation Studios XDev, Shift Up | Nintendo Switch 2, Microsoft Windows, PlayStation 5 |
| Stellar Dawn | — | Jagex | Java platform |
| Stephen's Sausage Roll | 2016 | Increpare games | Microsoft Windows, macOS, Linux |
| Steve Davis Snooker | — | — | Commodore 16, ZX Spectrum, Atari 8-bit family, Acorn Electron, Amstrad CPC, Sinclair QL, BBC Micro, Commodore Plus/4, Enterprise, Commodore 64 |
| Steve Davis World Snooker | — | — | Commodore Amiga, Atari ST |
| Steve Jackson's Sorcery! | 2022 | Inkle | Xbox One, Microsoft Windows, Xbox Series X and Series S |
| Steven Seagal Is: The Final Option | — | — | Sega Genesis/Mega Drive, Super Nintendo Entertainment System |
| Stick It to the Man! | 2013 | Zoink Games | Microsoft Windows, macOS, Nintendo Switch, PlayStation 4, Wii U |
| Sticky Balls | 2005 | Gizmondo | iOS, Gizmondo |
| Stifflip & Co. | 1987 | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Stikbold! A Dodgeball Adventure | 2016 | — | Microsoft Windows, macOS, Nintendo Switch |
| Still Wakes the Deep | 2024 | The Chinese Room | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Stirring Abyss | 2020 | — | Microsoft Windows |
| Stock Car | 1984 | — | Acorn Electron |
| Stolen | 2005 | — | PlayStation 2, Xbox, Microsoft Windows |
| Stone Protectors | 1994 | Eurocom | Microsoft Windows, Super Nintendo Entertainment System |
| Stonkers | 1983 | Imagine Software | Microsoft Windows, ZX Spectrum |
| Stop Disasters! | 2007 | — | web browser |
| Stories from Sol: The Gun-Dog | 2025 | — | Microsoft Windows, Nintendo Switch, Linux, PlayStation 4, PlayStation 5 |
| Stories Untold | 2017 | No Code | Microsoft Windows, macOS, Nintendo Switch, PlayStation 4 |
| Storm in a Teacup | 2012 | Cobra Mobile | Microsoft Windows, macOS, Nintendo Switch, iOS |
| Storm Warrior | 1989 | Elite Systems | Amstrad CPC, Commodore 64 |
| Stormbirds | — | THQ Digital Studios UK | PlayStation 3, Microsoft Windows, Xbox 360 |
| Stormbringer | 1987 | David Jones | ZX Spectrum, Amstrad CPC, MSX, Commodore 64 |
| Stormlord | 1989 | Hewson Consultants | Commodore Amiga, Sega Genesis/Mega Drive, DOS, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Stormrise | 2009 | Creative Assembly | PlayStation 3, Microsoft Windows, Xbox 360 |
| Stormworks: Build and Rescue | 2018 | Geometa | Microsoft Windows, macOS |
| Strange Antiquities | 2025 | — | Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Strange Brigade | 2018 | Rebellion Developments | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Strategic Command Classic: Global Conflict | 2010 | Fury Software | Microsoft Windows |
| Strategic Command Classic: WWI | 2011 | Fury Software | Microsoft Windows |
| Strategic Command Classic: WWII | 2006 | Fury Software | Microsoft Windows |
| Strategic Command WWII: War in Europe | 2016 | Fury Software | Microsoft Windows |
| Strategic Command WWII: World at War | 2018 | Fury Software | Microsoft Windows |
| Strategic Command: American Civil War | 2022 | Fury Software | Microsoft Windows |
| Strategic Command: World War I | 2019 | Fury Software | Microsoft Windows |
| Streaker | 1987 | — | ZX Spectrum, Amstrad CPC, MSX |
| Street Cleaning Simulator | 2011 | Astragon | Microsoft Windows |
| Street Fighter EX 2 Plus | 1999 | Arika | PlayStation, arcade video game machine, ZN-1 |
| Street Football 2 | 2009 | Dehon Games | Wii |
| Street Hawk | 1985 | — | ZX Spectrum, Amstrad CPC |
| Street Heat | 2019 | — | Microsoft Windows |
| Street Racer | 1994 | — | Sega Genesis/Mega Drive, PlayStation, Microsoft Windows, DOS, Super Nintendo Entertainment System, Game Boy, Amiga 1200 |
| Street Racing Syndicate | 2004 | Eutechnyx | PlayStation 2, Xbox, Microsoft Windows, Nintendo GameCube |
| Streets of London | 2011 | — | Commodore 64 |
| Strider II | 1990 | Tiertex Design Studios | Sega Genesis/Mega Drive, Sega Master System, ZX Spectrum, Amstrad CPC, Commodore 64 |
| Strike Fighters: Project 1 | 2002 | Third Wire | Microsoft Windows |
| Strike Force Cobra | 1986 | — | ZX Spectrum, Commodore 64 |
| Strike Force Harrier | 1986 | — | Commodore Amiga, ZX Spectrum, MS-DOS, Amstrad CPC, Atari ST, BBC Micro, Commodore 64 |
| Strike Solitaire | 2019 | Creobit | Microsoft Windows, iOS |
| Strike Solitaire 2 | 2020 | Creobit | Microsoft Windows |
| Strike Solitaire 3 | 2020 | Creobit | Microsoft Windows |
| Strike Suit Zero | 2013 | Born Ready Games Ltd. | Xbox One, Microsoft Windows, macOS, Nintendo Switch, Linux, PlayStation 4, Android |
| Striker | 1992 | Rage Games | Commodore Amiga, Sega Genesis/Mega Drive, DOS, Super Nintendo Entertainment System |
| Striker '96 | 1996 | — | PlayStation, Microsoft Windows, Sega Saturn |
| Stronghold | 2001 | Firefly Studios | Microsoft Windows, macOS |
| Stronghold 2 | 2005 | Firefly Studios | Microsoft Windows |
| Stronghold 3 | 2011 | Firefly Studios | Microsoft Windows, macOS, Linux |
| Stronghold 4 | 2026 | Firefly Studios | Microsoft Windows |
| Stronghold Crusader 2 | 2014 | Firefly Studios | Microsoft Windows |
| Stronghold Crusader: Definitive Edition | 2025 | Firefly Studios | Microsoft Windows |
| Stronghold Kingdoms | 2012 | Firefly Studios | Microsoft Windows, iOS, Android |
| Stronghold Legends | 2006 | Firefly Studios | Microsoft Windows, personal computer |
| Stronghold: Crusader | 2002 | Firefly Studios | Microsoft Windows |
| Stronghold: Crusader Extreme | 2008 | Firefly Studios | Microsoft Windows |
| Stronghold: Warlords | 2021 | Firefly Studios | Microsoft Windows |
| Strontium Dog and the Death Gauntlet | 1984 | Quicksilva | Commodore 64 |
| Strontium Dog: The Killing | 1984 | — | ZX Spectrum |
| Struggling | 2020 | Chasing Rats Games | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Stryker's Run | 1986 | Chris Roberts | BBC Micro |
| Stuart Little: The Journey Home | 2001 | Tiertex Design Studios | Game Boy Color |
| Stunt Car Racer | 1989 | MicroProse | Commodore Amiga, Microsoft Windows, DOS, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Stunt GP | 2001 | Team17 | PlayStation 2, Microsoft Windows, Dreamcast |
| Stunt Island | 1992 | The Assembly Line | DOS |
| Stunt Kids | — | Codemasters | Nintendo Entertainment System |
| Stunt Race FX | 1994 | Nintendo Entertainment Analysis & Development | Super Nintendo Entertainment System |
| Stuntman | 2002 | Ubisoft Reflections | PlayStation 2, Game Boy Advance |
| Styx | 1983 | Matthew Smith | ZX Spectrum |
| Sub Command | 2001 | — | Microsoft Windows |
| Sub Culture | 1997 | Criterion Games | Microsoft Windows |
| Submarine TITANS | 2000 | — | Microsoft Windows |
| SubSpace | 1997 | Virgin Interactive | Microsoft Windows |
| Subsunk | 1985 | — | ZX Spectrum, Amstrad CPC |
| Subsurface Circular | 2017 | Mike Bithell | Microsoft Windows, macOS, Nintendo Switch, iOS |
| Subversion | — | Introversion Software | — |
| Subwar 2050 | 1993 | Particle Systems | Microsoft Windows, macOS, DOS, Linux |
| Sudeki | 2004 | Climax Studios | Xbox, Microsoft Windows |
| Suicide Squad: Kill The Justice League | 2024 | Rocksteady Studios | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Suicide Squad: Special Ops | 2016 | Sticky Studios | iOS, Android |
| Sultan's Maze | 1983 | — | Dragon 32/64 |
| Summer Games | 1984 | Epyx | Atari 2600, ZX Spectrum, Atari 7800, Commodore 64 |
| Summer Games II | 2008 | Epyx | Commodore Amiga, DOS, ZX Spectrum, Atari ST, Commodore 64 |
| Summer Heat Beach Volleyball | 2003 | Acclaim Entertainment | PlayStation 2 |
| Summer Session | 2008 | Hanako Games | Microsoft Windows, macOS |
| Summerhouse | 2024 | — | Microsoft Windows, macOS, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Sunday Gold | 2022 | BKOM Studios | Microsoft Windows |
| Sunless Sea | 2015 | Failbetter Games | Microsoft Windows, macOS, Linux, iOS |
| Sunless Sea: Zubmariner | 2016 | — | Microsoft Windows, macOS, Linux, iOS, PlayStation 4 |
| Sunless Skies: Sovereign Edition | 2019 | Failbetter Games | Microsoft Windows, macOS, Linux, PlayStation 4 |
| Sunshine Manor | 2021 | — | Microsoft Windows, macOS, Linux, PlayStation 4 |