| U Host | 2016 | — | Wii U |
| U.S. Special Forces: Team Factor | 2002 | — | Microsoft Windows |
| Ubersoldier II | 2014 | Burut CT | Microsoft Windows |
| UEFA Challenge | 2001 | Infogrames | PlayStation 2, Microsoft Windows |
| UEFA Champions League 1996/97 | 1997 | Krisalis Software | DOS |
| UEFA Champions League Season 1998/99 | 1999 | Silicon Dreams Studios | PlayStation, Microsoft Windows |
| UEFA Champions League Season 1999/2000 | 2000 | Silicon Dreams Studios | PlayStation, Microsoft Windows |
| UEFA Euro 96 | 1996 | Gremlin Interactive | Microsoft Windows, DOS, Sega Saturn |
| UEFA Striker | — | Rage Games | — |
| UFO: Enemy Unknown | 1994 | Mythos Games | PlayStation, Microsoft Windows, DOS, Amiga 1200 |
| UK Truck Simulator | 2010 | SCS Software | Microsoft Windows |
| Ultima VI: The False Prophet | 1990 | Origin Systems | Commodore Amiga, DOS, Sharp X68000, Super Nintendo Entertainment System, NEC PC-9800 series, FM Towns, Atari ST, Commodore 64 |
| Ultimate Body Blows | 1994 | Team17 | DOS |
| Ultimate Brain Games | — | — | Atari Jaguar |
| Ultimate I Spy | 2008 | Gusto Games | Wii |
| Ultimate Soccer | 1993 | Rage Games | Sega Genesis/Mega Drive, Sega Master System, Game Gear |
| Ultimate Soccer Manager | 1995 | Impressions Games | Commodore Amiga, DOS |
| Ultimate Yahtzee | 1996 | Hasbro Interactive | Microsoft Windows, Windows 3.x |
| Ultratron | 2013 | Puppy Games | Microsoft Windows, macOS, Linux |
| Unbeatable | 2025 | — | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Unbox: Newbie's Adventure | 2016 | Prospect Games | Microsoft Windows, PlayStation 4 |
| Uncle Chop's Rocket Shop | 2024 | Beard Envy | Microsoft Windows, Nintendo Switch, PlayStation 5, Xbox Series X and Series S |
| Under a Killing Moon | 1994 | Indie Built | Classic Mac OS, Microsoft Windows, macOS, DOS, Linux, iOS |
| Under Defeat HD | 2012 | G.rev | PlayStation 3, Microsoft Windows, Nintendo Switch, Xbox 360, PlayStation 4, PlayStation 5, Xbox Series X and Series S |
| Under Development | 2011 | MDickie Limited | Microsoft Windows |
| Underworld: The Eternal War | 2004 | Lucky Chicken Games | PlayStation 2 |
| Underwurlde | 1984 | Stamper brothers | ZX Spectrum, Commodore 64 |
| Undisputed | 2023 | Steel City Interactive | Microsoft Windows, PlayStation 5, Xbox Series X and Series S |
| Unhinged | — | — | Microsoft Windows |
| Uniracers | 1994 | Rockstar North | Super Nintendo Entertainment System |
| Unity | 2004 | Jeff Minter | Nintendo GameCube |
| Universal Hero | 1986 | — | ZX Spectrum |
| Universal Soldier | 1992 | The Code Monkeys | Sega Genesis/Mega Drive, Game Boy |
| Universe | 1994 | Core Design | Commodore Amiga, DOS, Amiga CD32 |
| Unlimited Escape | 2015 | — | Microsoft Windows |
| Unlimited Escape 2 | 2015 | — | Microsoft Windows |
| Unlimited Escape 3 & 4 Double Pack | 2015 | — | Microsoft Windows |
| Uno | 1999 | — | Game Boy Color |
| Unsolved Crimes | 2008 | Now Production | Nintendo DS |
| Untamed: Life Of A Cougar | 2015 | — | Microsoft Windows |
| Until Dawn | 2024 | Ballistic Moon | Microsoft Windows, PlayStation 5 |
| Until Dawn | 2015 | Supermassive Games | PlayStation 4 |
| Until Dawn 2 | 2027 | Firesprite | PlayStation 5 |
| Until Dawn: Rush of Blood | 2016 | Supermassive Games | PlayStation 4 |
| Uphill: Sierra Nevada Fire Rescue | — | Uphill Games | web browser |
| Uplink | 2001 | Introversion Software | Microsoft Windows, macOS, Linux, iOS, Android |
| Upside-Down Dimensions | 2017 | — | Microsoft Windows, macOS, PlayStation Vita, Linux |
| Urban Chaos | 1999 | Mucky Foot Productions | PlayStation, Microsoft Windows, Dreamcast |
| Urban Chaos: Riot Response | 2006 | Rocksteady Studios | PlayStation 2, Xbox |
| Urban Dead | 2005 | — | web browser |
| Urban Extreme: Street Rage | 2008 | Data Design Interactive | Wii |
| Urban Terror | 2000 | — | Microsoft Windows, macOS, Linux |
| Urban Upstart | 1983 | Pete Cooke | ZX Spectrum, Commodore 64 |
| Uridium | 1986 | Andrew Braybrook | DOS, ZX Spectrum, Amstrad CPC, iOS, Atari ST, Commodore 64 |
| Uridium 2 | 1993 | Andrew Braybrook | Commodore Amiga |
| US and THEM | 2010 | — | Microsoft Windows |
| Utopia City | 2005 | Parallax Arts Studio | Microsoft Windows |
| Utopia: The Creation of a Nation | 1991 | — | Commodore Amiga, DOS, Super Nintendo Entertainment System, Atari ST |
| UTour Golf | 2007 | — | SkillGround |