| Scooby-Doo and the Cyber Chase | 2001 | Art Co., Ltd | Game Boy Advance |
| Uplink | 2001 | Introversion Software | Microsoft Windows, macOS, Linux, iOS, Android |
| Monopoly Tycoon | 2001 | DR Studios | Microsoft Windows, mobile phone |
| Robot Wars: Advanced Destruction | 2001 | — | Game Boy Advance |
| Diggles: The Myth of Fenris | 2001 | Spieleentwicklungskombinat | Microsoft Windows |
| Lego Racers 2 | 2001 | — | PlayStation 2, Microsoft Windows, Game Boy Advance |
| Dexter's Laboratory: Deesaster Strikes! | 2001 | — | Game Boy Advance |
| Rugrats: Castle Capers | 2001 | Software Creations | Game Boy Advance |
| The Weakest Link | 2001 | Traveller's Tales | PlayStation, PlayStation 2, Microsoft Windows |
| Tiny Toon Adventures: Plucky's Big Adventure | 2001 | Warthog Games | PlayStation |
| Commandos 2: Men of Courage | 2001 | Pyro Studios | PlayStation 2, Xbox, Microsoft Windows, macOS |
| F1 2001 | 2001 | Image Space Incorporated | PlayStation 2, Xbox, Microsoft Windows |
| SpongeBob SquarePants: SuperSponge | 2001 | Climax Studios | PlayStation, Game Boy Advance |
| Barbie Explorer | 2001 | Runecraft | PlayStation, Microsoft Windows |
| Dave Mirra Freestyle BMX 2 | 2001 | Underground Development | PlayStation 2, Xbox, Nintendo GameCube, Game Boy Advance |
| Extreme-G 3 | 2001 | Acclaim Studios London | PlayStation 2, Nintendo GameCube |
| Stuart Little: The Journey Home | 2001 | Tiertex Design Studios | Game Boy Color |
| Dragonriders: Chronicles of Pern | 2001 | Ubisoft | Microsoft Windows, Dreamcast |
| Max Payne | 2001 | Remedy Entertainment | PlayStation 2, Xbox, Microsoft Windows, macOS, Game Boy Advance, iOS, Android |
| Rugby | 2001 | Creative Assembly | PlayStation 2, Microsoft Windows |
| Tomb Raider: Curse of the Sword | 2001 | Core Design | Game Boy Color |
| Tiny Toon Adventures: Buster Saves the Day | 2001 | Warthog Games | Game Boy Color |
| Anachronox | 2001 | Ion Storm | Microsoft Windows |
| Hot Potato | 2001 | — | Game Boy Advance |
| Independence War 2: Edge of Chaos | 2001 | Particle Systems | Microsoft Windows |
| Wacky Races Starring Dastardly and Muttley | 2001 | Infogrames | PlayStation 2 |
| Hard Hitter Tennis | 2001 | Magical Company | PlayStation 2 |
| Poseidon: Master of Atlantis | 2001 | Impressions Games | Microsoft Windows |
| Operation Flashpoint: Cold War Crisis | 2001 | Bohemia Interactive | Xbox, Microsoft Windows, macOS, Linux |
| Original War | 2001 | Altar Games | Microsoft Windows |
| Z: Steel Soldiers | 2001 | The Bitmap Brothers | Microsoft Windows, iOS, Android |
| Emperor: Battle for Dune | 2001 | Westwood Studios, Intelligent Games | Microsoft Windows |
| Army Men Advance | 2001 | DC Comics | Game Boy Advance |
| Maken X | 2001 | Atlus | PlayStation 2, Dreamcast |
| Dinosaur World | 2001 | Asylum Entertainment | Microsoft Windows |
| Gangsters 2 | 2001 | Hothouse Creations | Microsoft Windows |
| World War II Online | 2001 | — | Microsoft Windows, macOS |
| Commander Keen | 2001 | — | Game Boy Color |
| Exhibition of Speed | 2001 | Titus Interactive | Dreamcast |
| Mat Hoffman's Pro BMX | 2001 | Shaba Games | Microsoft Windows, Dreamcast, Game Boy Advance |
| Eurofighter Typhoon | 2001 | Digital Image Design | Microsoft Windows |
| Scorched 3D | 2001 | — | Microsoft Windows, macOS, Linux |
| E-Racer | 2001 | Rage Games | Microsoft Windows |
| Tropico | 2001 | PopTop Software, Feral Interactive | Classic Mac OS, Microsoft Windows, macOS |
| Formula One 2001 | 2001 | Studio 33 | PlayStation, PlayStation 2 |
| Power Rangers Time Force | 2001 | Winning Entertainment Group | Microsoft Windows, Game Boy Advance |
| California Watersports | 2001 | Midas Interactive Entertainment | PlayStation |
| C-12: Final Resistance | 2001 | Guerrilla Cambridge | PlayStation |
| Snoopy Tennis | 2001 | — | Game Boy Color |
| Stunt GP | 2001 | Team17 | PlayStation 2, Microsoft Windows, Dreamcast |
| Worms World Party | 2001 | Team17 | PlayStation, Microsoft Windows, Dreamcast, Game Boy Advance, N-Gage, PlayStation 4 |
| UEFA Challenge | 2001 | Infogrames | PlayStation 2, Microsoft Windows |
| LEGO Island 2: The Brickster's Revenge | 2001 | Silicon Dreams Studios, Crawfish Interactive | PlayStation, Microsoft Windows |
| Tweenies: Game Time | 2001 | BBC Multimedia | PlayStation |
| Air Ranger: Rescue Helicopter | 2001 | ASK Group | PlayStation 2 |
| Three Kingdoms: Fate of the Dragon | 2001 | — | Microsoft Windows |
| The Simpsons: Night of the Living Treehouse of Horror | 2001 | Software Creations | Game Boy Color |
| Black & White | 2001 | Lionhead Studios | Classic Mac OS, Microsoft Windows, macOS |
| Hostile Waters: Antaeus Rising | 2001 | Rage Games | Microsoft Windows |
| F1 World Grand Prix 2000 | 2001 | Eutechnyx | PlayStation, Microsoft Windows |