| Seas of Blood | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| Sega Arcade Gallery | — | Sega | Game Boy Advance |
| Seiddab Trilogy | — | Graftgold | ZX Spectrum |
| Seymour Goes to Hollywood | — | Big Red Software | Commodore Amiga, DOS, ZX Spectrum, Amstrad CPC, Atari ST, Commodore 64 |
| Signet City | — | Jump Over the Age | Microsoft Windows |
| Simon Tatham's Portable Puzzle Collection | — | Simon Tatham | — |
| SimSig | — | — | Microsoft Windows |
| SingStar '90s | — | Sony Interactive Entertainment Europe | PlayStation 2 |
| SingStar The Dome | — | — | PlayStation 2 |
| Sky Surfer | — | Toka | PlayStation 2 |
| Sneaky Snakes | — | Rare Ltd. | Game Boy |
| Sporting Triangles | — | — | ZX Spectrum, Amstrad CPC |
| Spy Snatcher | — | — | ZX Spectrum, Amstrad CPC, Amstrad PCW |
| Stack Light Rifle | — | — | ZX Spectrum |
| Star Citizen | — | Cloud Imperium Games | Microsoft Windows |
| Starch | — | — | Acorn Archimedes |
| Steel | — | — | Commodore Amiga |
| Stellar Dawn | — | Jagex | Java platform |
| Steve Davis Snooker | — | — | Commodore 16, ZX Spectrum, Atari 8-bit family, Acorn Electron, Amstrad CPC, Sinclair QL, BBC Micro, Commodore Plus/4, Enterprise, Commodore 64 |
| Steve Davis World Snooker | — | — | Commodore Amiga, Atari ST |
| Steven Seagal Is: The Final Option | — | — | Sega Genesis/Mega Drive, Super Nintendo Entertainment System |
| Stormbirds | — | THQ Digital Studios UK | PlayStation 3, Microsoft Windows, Xbox 360 |
| Stunt Kids | — | Codemasters | Nintendo Entertainment System |
| Subversion | — | Introversion Software | — |
| Super Doodle Bomber | — | Lionhead Studios | Microsoft Windows |
| Super Foul Egg | — | — | Acorn Archimedes |
| Super League Manager | — | — | Commodore Amiga |
| Sure Shot | — | MDickie Limited | Microsoft Windows |
| Sure Shot: Star Wars Edition | — | MDickie Limited | Microsoft Windows |
| Suzuki Alstare Extreme Racing | — | Criterion Games | — |
| Suzuki TT Superbikes | — | — | PlayStation 2 |
| Talisman | — | Nomad Games | Android |
| Taskmaster VR | — | — | Microsoft Windows |
| Team Apache | — | Simis | Microsoft Windows |
| Tempest 3000 | — | — | Nuon |
| Temple of Terror | — | Adventure Soft | ZX Spectrum, Commodore 64 |
| Tennis Arena | — | — | PlayStation, Sega Saturn |
| The Biz | — | Virgin Group | ZX Spectrum |
| The Dreamland Chronicles: Freedom Ridge | — | Mythos Games | PlayStation 2 |
| The Elder Scrolls Travels: Oblivion | — | Climax Studios | PlayStation Portable |
| The Great Space Race | — | Legend | ZX Spectrum |
| The Indestructibles | — | Bullfrog Productions | — |
| The Island | — | — | ZX Spectrum |
| The Kristal | — | — | DOS |
| The Last Night | — | — | Microsoft Windows, macOS, Linux |
| The Making of a Prophet | — | MDickie Limited | Microsoft Windows |
| The Outsider | — | Frontier Developments | PlayStation 3, Microsoft Windows, Xbox 360 |
| The Ren & Stimpy Show: Fire Dogs | — | Argonaut Games | Super Nintendo Entertainment System |
| The Thompson Twins Adventure | — | Quicksilva | ZX Spectrum |
| The Ultimate Stuntman | — | Codemasters | Nintendo Entertainment System |
| The Wild Bunch | — | — | ZX Spectrum, Amstrad CPC, Commodore 64 |
| This is Football | — | — | PlayStation |
| This is Football 2 | — | — | PlayStation |
| This is Football Management | — | — | PlayStation 3, PlayStation Portable, PlayStation Vita |
| This Is Pool | — | VooFoo Studios | Xbox One, Microsoft Windows, Nintendo Switch, PlayStation 4 |
| Thrill Kill | — | Midway Studios – Los Angeles | PlayStation |
| ThunderJaws | — | Atari Games | Commodore Amiga, ZX Spectrum, Amstrad CPC, Commodore 64 |
| TimeSplitters 4 | — | Crytek UK | PlayStation 2 |
| Tip Off | — | Anco Software | Commodore Amiga, Atari ST |
| Titan A.E. | — | Blitz Games Studios | PlayStation |